ADAPT: Active Awards

National Institute of Mental Health (NIMH) R01 120088

Title: CAPER: Computerized Assessment for Psychosis Risk 1R01MH120088-01A1

Principal Investigators: Vijay Mittal, Jim Gold,

Total Direct Costs: $8,125,402

Project: 4/01/2020-3/30/2025

Site PIs: Jim Gold, Vijay Mittal, Lauren Ellman, Gregory Strauss, Phil Corlett/Scott Woods

Co-Is: Elaine Walker, Steve Silverstein, Albert Powers, Rick Zinbarg, Shou Chen

Goal: To examine the value of including markers sensitive to disease course and amenable to computational approaches and utilize these to develop a new computerized battery for risk assessment of youth at clinical high-risk for psychosis.

National Institute of Mental Health R01MH134369

Title: Motor features of the voice as indicators of psychomotor agitation and retardation in current and remitted MDD

Dates: 4/2024-3/2029

MPI: Stewart A. Shankman, Vijay A Mittal, Matthew Goldrick

Co-Investigators: Yosi Keshet, Sebastian Walther

Total Direct Costs: 2.5 million

Goal: Examination of vocal features as a biomarker for motor symptoms and disease progression in affective disorders.

National Institute of Mental Health R01

Title: Estrogen and Mechanisms of Psychotic-like Experiences in the Transition to Adolescence

Dates: 7/1/2024-6/31/26

PI: Mittal

Co-Investigators: Katherine Damme, Daniel Mroczek, Jennifer Pfiefer

Total Direct Costs: 275k

Goal: Examine estrogen and psychosis-like experiences along with brain development and risk in the ABCD dataset.

National Institute of Mental Health R01MH116039-01A1

Title: Prodromal Inventory for Negative Symptoms: Development and Validation

Principal Investigator: Vijay Mittal, Greg Strauss

Project: 3/01/2019-11/30/2024 (NCE)

Total Direct Costs: $2,458,416

Co-Is: Elaine Walker, Brain Kirkpatrick, Bill Horan, Paul Grant, Rick Zinbarg

Goal: To develop a high sensitive inventory for detecting early negative symptomatology in youth at risk for psychotic disorders.

National Institute of Mental Health (NIMH) U01 MH124639-01

Title: Psychosis-risk outcomes network: ProNET

Principal Investigators: Scott Woods (Yale), Carrie Bearden (UCLA), John Kane

Site PIs: Vijay Mittal (Northwestern), Fred Sabb (Oregon), William Stone (Harvard, Shanghai), Barbara Cornblatt (Northwell), Diana Perkins (UNC), Kristin Caadenhead (UCSD), , Jean Addington, (Calgary), Daniel Mathalon (UCSF), Monica Calkins/Daniel Wolf (Penn), Cheryl Corcoran, Mt. Sinai, Leslie Horton (Pittsburgh), Jason Schiffman (UMBC), Laruen Ellman, (Temple), Greg Strauss (UGA), Daniel Mamah (Washington University), Jimy Choi, Godfrey Pearlson (Hartford), , Jai Shah (Montreal), Paolo Fusar-Poli (Kings College, Pavia), Celso Arango (Madrid), Jesus Perez (Cambridge), Nikos Koutsouleris (Munich), Jun Soo Kwon (Seoul).

Co-Is: Stewart Shankman

Proposed Project Period: 9/1/20-8/2025

Total Direct Costs: 55 million (Northwestern Site Directs: 1.24 million)

Goal: Develop a treatment development network capable of examining treatment related biomarkers as well as mapping in-depth clinical outcome measures.

National Institute of Mental Health 1R01MH112545-01

Title: 2/3 Community psychosis risk screening: An instrument development study

Principal Investigator: Vijay Mittal, Lauren Ellman, Jason Schiffman

Project Period: 7/2017-7/2024 (NCE)

Total Direct Costs: $2,500,000.00

CO-Is: Thomas Olino, Waren Bilker

Goal: This study, including sites in Chicago, Philadelphia, and Baltimore, will recruit 12,000 adolescent and young adult participants with the aim of developing a screening designed to identify non help-seeking community youth who are likely to meet criteria for a psychosis risk syndrome.

National Institute of Mental Health R01 MH118741

Title: An examination of psychomotor disturbance in current and remitted MDD: An RDoC Study

PIs: Stewart Shankman, Vijay Mittal, Sebastian Walther

Total Direct Costs: $2,500,000

Project Period: 4/1/2019-3/31/2025 (NCE)

Co-Is: Jessica Bernard, Alex Leow

Consultant: Vinod Menon

Goal: Study motor symptoms in depression from RDoC Framework, and develop a mobile platform for utilizing these markers as an early identification/treatment decision informatics system.

National Institute of Mental Health R01

Title: Social Processing Deficits in Remitted Adolescent Depression Dates: 12/9-12/25 (NCE)

MPI: Corresponding PI: Randy P. Auerbach; PI: Stewart A. Shankman

Co-Investigators: Vijay Mittal; Jürgen Kayser; Laura Mufson; Linda Valeri; Nicholas Allen

Total Direct Costs: 2.5 million

Goal: examine several modalities of social processing, including a novel eye-tracking gestures social perception task.

Executive Committee for Training and High-Risk Research Programs

National Institute of Mental Health T32 MH126368

Title: Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology

PI: Shankman & Wakschlag

Date: 2021-2025

Role: Steering Committee

NIMH NURTURE Grant, 2022-2025

Title: Interventions for Changes in Emotions, Perceptions and Thinking (Intercept)- Foundation and Sate Supported Clinical High-Risk Research Clinic

Date: 2023-Presnt

Director: Steve Silverstein

Site: University of Rochester, Department of Psychiatry

Role: Advisory Board Member

PIs: Melissa Simon, Eric Perrault, Clyde Yancy

Role: Leadership Council, Scientific Neighborhood Faculty, Brain, Mind, and Behavior

Goal: transform culture at NIH-funded extramural institutions by building a self-reinforcing community of scientists committed to diversity and inclusive excellence.

Mentored Awards

NIMH National Research Service Award. NRSA 1F32MH139246

Title: The role of mental imagery in perceptual abnormality formation in individuals at clinical high-risk for psychosis

Danielle Pratt 2024-2026

Mentor: Mittal, Corlett

Goal: To examine computational processes related to perceptual abnormalities in CHR individuals.

NIMH National Research Service Award. NRSA 1F31MH139284

Title: EEG coherence as a biomarker for Psychomotor Disturbance and Course of Depression

Vanessa Zarubin 2024-2026

Mentor: Mittal, Shankman

Goal: To examine neural correlates of psychomotor retardation in depression utilizing resting state EEG.

Brain and Behavior Research Foundation, NARSAD Young Investigator Award

Principle Investigator: Danielle Pratt

Project Period: 1/15/2025-1/14/27

Total Direct Costs: $60,000

Goal: To determine the cognitive contributions to the experience of perceptual aberrations in those at risk for psychosis.

Mentor: Mittal

National Institute of Aging, Transition to Aging Research for Predoctoral Students (F99/K00) Award 1F99AG088569-01

Title: Precision mapping of functional networks in healthy and pathological aging

Dates: 2024-2025

Sponsors: Gratton, Mittal

Goal: To examine and characterize individual differences in functional brain networks during healthy aging (pre-doctoral phase) and pathological aging (post-doctoral phase)

NIMH Mentored Patient-Oriented Research Career Development Award. K23MH129607

Title: Clarifying the Role of Psychomotor Retardation in Reward-Based Reinforcement Learning Deficits in MDD: A Computational and fMRI Study

Allison Letkiewicz 2022-2027

Mentor: Mittal, Shankman

Goal: To examine the impact of psychomotor slowing on reward-based reinforcement learning in depression

Completed Research Support

Brain Behavior Research Foundation Independent Investigator Award, (NARSAD)

Title: Brain stimulation targeting cerebellar-cortical circuits and verbal working memory in psychosis

Principal Investigator: Vijay Mittal

Project Period: 3/15/2018-3/14/2023 (NCE)

Total Direct Costs: $100,000

Co-I: Jessica Bernard

Goal: A functional magnetic resonance imaging (fMRI), double-blind cross over study designed to determine if targeted cerebellar brain stimulation will normalize brain activation and behavioral task performance in individuals with schizophrenia performing a verbal working memory task.

National Institute of Mental Health R21 MH115231

Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction

Principal Investigators: Claudia Haase, Vijay A Mittal

Project Period: 9/2017-8/30/2022 (NCE)

Total Direct Costs: $275,000

Goal: Project will examine adolescents at high-risk for psychosis and caretakers in a dyadic interaction task to evaluate if patterns of aberrant emotional arousal and regulation predict course of illness.

National Institute of Mental Health R21, Supplement

Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction

PIs: Haase, Mittal

Project Period: 9/2017-8/30/2022 (NCE)

Total Direct Costs: $30,000

Goal: To evaluate interactive variables from pairs of care-taker/youth in the context of clinical course.

National Institute of Mental Health R21 MH119677

Title: Language features and High-Risk Psychosis Youth

Principal Investigators: Matthew Goldrick, Vijay A Mittal

Project Period: 4/2019-12/31/2023 (NCE)

Total Direct Costs: $275,000

Goal: Project will examine vocal features from the perspective that they may represent a sign of motor dysfunction in youth at high risk for psychosis. We will use a computational approach to linguistic feature and pattern analysis and follow high-risk youth over time to track course and develop predictive models.

Substance Abuse and Mental Health Services SAMHSA CHP-R Federal Grant SM-18-012

Title: Community Programs for Outreach and Intervention with Youth and Young Adults at Clinical High Risk for Psychosis

Total Direct Costs: $1,600,000

PIs: State of Illinois, Thresholds

Project Period: 12/2018-11/2022

Consultant: Mittal, Hooker

Goal: To implement a stepped care model to treatment of prodromal syndromes in the Illinois healthcare system.

Northwestern Weinberg College Research and Innovation Grant W Award

Title: Using motor control disruptions in speech to predict risk for psychotic disorders

Direct Costs: $35,000

Project Period: 9/2017-8/2018

Goal: To develop software for analyzing speech patterns indicating increased risk for psychosis.

National Institute of Mental Health Translational Research for the Development of Novel Interventions for Mental Disorders: R21/R33 Award, MH103231

Title: Exercise and markers of medial temporal health in youth at ultra high-risk for psychosis

Principal Investigators: Vijay Mittal, Ph.D., Angela Bryan

Project Period: 07/2014-6/2020 (NCE)

Total Direct Costs: $850,000

Co-I: Randal Ross, M.D.

Goal: To test feasibility and to design a pilot controlled trial investigation of cardiovascular exercise and medial temporal neurogenesis and cognitive/functioning remediation in youth at high-risk for schizophrenia.

National Institute of Mental Health R21 MH110374

Title: Neural Habituation in Ultra High-Risk Youth

Principal Investigators: Vijay Mittal

Project Period: 4/2017-3/30/2021 (NCE Y2)

Total Direct Costs: $275,000

Co-Is: Timothy Curran, Robin Nusslock

Consultant: Holly Earls

Goal: This project will examine how neural habituation (i.e., a decrease in neural activation to repeated stimuli) is related to social processing deficits in ultra high-risk youth (UHR), a group at imminent risk for transitioning to a psychotic disorder. The project utilizes electroencephalography (EEG) to examine whether neural habituation abnormalities in the P100 component (associated with early visual perception), and N170 repetition effect (associated with visual object recognition and learning) are specific to social stimuli (emotional and/or neutral faces) or generalize to non-face objects.

National Institute of Health, R01MH094650

Project Title: Motor Measures of Basal Ganglia and Cerebellar Circuit Dysfunction in Psychosis

Principal Investigator: Vijay A. Mittal, Ph.D.

Project Period: 06/01/2011-02/29/2018

Total Direct Cost: $1,820,544

CO-Is: Randal Ross, M.D., Marie Banich Ph.D.

Goal: Investigate spontaneous movement abnormalities as a potential biomarker for white matter and grey matter development components of frontal-subcortical circuits, in adolescents at high-risk for psychosis.

Northwestern Data Science Initiative Award

Title: Automated analysis of vocal characteristics for early detection of schizophrenia

Total Award: $30,000

Dates: 06/2016-05/2017

P.Is: Matthew Goldrick, Emily Cibelli, Vijay Mittal

Goal: To Evaluate early motor dysfunction in speech signifying risk for psychosis.

Buffett Institute for Global Study, Scholars in Israel Collaboration

Title: A Multidisciplinary Approach to Predicting Schizophrenia

P.Is: Matthew Goldrick, Vijay Mittal, Emily Cibelli, Joseph Keshet, Yossi Adi, Jennifer Cole

Date: 06/2017-5/2017

Total Award: $25,000

Goal: To use machine learning to evaluate movement markers of risk for psychosis.

Intermountain Neuroimaging Consortium (INC) Pilot Award

Title: Default Mode Network Hyperconnectivity Across the Schizophrenia Spectrum

PI: Mittal and Turner

Project Period: 2012-2013

Goal: To examine potential hyperconnectivity patterns across the psychosis spectrum.

National Institute of Health (NIH) Clinical Research Loan Repayment Award (2009-2012), NIH- L30 MH087258:01-02

Title: Dyskinetic Movements and Glucocorticoids in Adolescents At-Risk for Psychosis

Principal Investigator: Vijay A. Mittal, Ph.D.

Goal: This project is designed to investigate the roles between stress reactivity, reciprocal dopamine activation, and potentially consequent neuromotor dysfunction.

Completed Mentored Awards

NIMH National Research Service Award. NRSA 1F32MH133302-01A1

Title: Paranoia and Bias in Social Belief Updating in Clinical High Risk for Psychosis

Trevor Williams 2023-2025

Mentor: Mittal, Corlett

Goal: To examine computational and social cognitive processes related to paranoia in CHR individuals.

NIMH National Research Service Award, F31MH123121 decisions

Title: The Neural Mechanisms of Motor Dysfunction in Clinical High-Risk Youth

Juston Osborne 2020-2022

Mentor: Mittal

Goal: To examine motor psychophysiology (e.g., LRP, CNV) and develop biomarkers in CHR youth.

NIMH National Research Service Award. NRSA 1F31MH121018-01A1

Title: Neurocorrelates of alterations in facial expressivity in youth at clinical high-risk for psychosis

Tina Gupta 2019-2021

Mentor: Mittal, Haase

Goal: To examine underlying neural circuitry in motor and limbic networks of alterations in facial expressivity in psychosis risk.

NIMH National Research Service Award. NRSA 1F31MH119776-01A1

Title: Cumulative environmental risk exposure in youth at clinical high-risk for psychosis

Teresa Vargas 2019-2022

Mentor: Mittal, McDade

Goal: To examine if stress during different developmental periods influences adult brain dysfunction and psychosis risk.

National Academy of Science, Ford Fellowship

Title: Early life stress and adult brain structure and cognition

PI: Teresa Vargas

Project Period: 6/2019-5/2022

Mentor: Vijay Mittal

Goal: To examine how early experience shape brain development and influence the way people interact with the world they live in.

Canadian Institutes of Health Research (CIHR), Doctoral Foreign Study Award (DFSA)

Title: Cortical Midline Structures and Self-Reflection in youth at ultra-high risk for psychosis

PI: Raffles Cowan

Dates: 9/2017-8/2020

Mentors: Dan McAdams, Vijay Mittal

Goal: To use narrative interviewing and resting stage imaging methods to understand aberrant self-reflection in high-risk youth.

Brain and Behavior Research Foundation, NARSAD Young Investigator Award

Title: Emotion, Mental Health, and Epigenetic clock in high-risk caregivers

Principle Investigator: Claudia Haase

Project Period: 12/2017-11/19

Total Direct Costs: $60,000

Sponsors: Mittal, Alexander

Goal: To determine how negative emotion during dyadic interaction predicts accelerated epigenetic aging in caregivers of youth at risk for psychosis.

Brain and Behavior Research Foundation, NARSAD Young Investigator Award

Title: Elucidating the Role of Abnormal Motor Resonance in Social Cognition Deficits in Schizophrenia

PI: Jerillyn Kent

Project Period: 12/2017-11/19

Total Direct Costs: $60,000

Sponsors: Scott Sponheim

Mentoring Collaborator: Vijay Mittal

Brain Behavior Research Foundation (formally NARSAD): Young Investigator Award

Title: Cerebello-Prefrontal Involvement in Error Processing and Rule Learning in Youth at Ultra High-Risk for Psychosis

Project Period: 1/1/2015-1/1/2017

Total Direct Costs: $60,000

P.I.: Jessica Bernard, Ph.D.